While those authors have studied the IL-1RI+ cells, which represent 20% of CD4+ cells in healthy donors, and identified that the frequency of naive CD4+ cells is lower, while the frequency of memory CD4+ cells is higher in IL-1RI+ than in IL-1RI− cells, our results provide further insight into the differential gene expression of IL-1RI in both CD4+ cell subsets in RR MS patients in comparison to HCs. Here, CD4 is linked to myeloid sarcoma.