The deletion of the genes for cfhr1 and cfhr3 are a double-edged sword as it was genetically associated with protection against age-related macular degeneration (AMD) (9–11) and IgA nephropathy (IgAN) (12), or was associated to be a genetic risk factor for atypical hemolytic-uremic syndrome (aHUS) (13, 14) as well as systemic lupus erythematosus (SLE) (15). Here, CFHR3 is linked to age-related macular degeneration.