By contrast, TLR5 mRNA expression on peripheral blood, especially in the Lin(−)HLADR(−)CD33(+) CD16(+) and CD14(++)CD16(−) monocytes, was increased in the patients with GVHD after receiving adaptive Treg infusion for prevention of GVHD in human (30). The gene discussed is TLR5; the disease is graft versus host disease.