As binge drinking-induced TNF-α production and liver injury could be effectively attenuated by antioxidant (N-acetylcysteine) and specific inhibitor of CYP2E1 (chlormethiazole), it could be concluded that oxidative stress might mediate endotoxin/LPS-induced TNF-α production in acute ethanol-induced liver injury (52, 115). The gene discussed is TNF; the disease is injury.