Recently, we showed that SOD1 activates muscarinic M1 receptor inducing a phosphorylation of ERK1/2 and AKT in a dose and time dependent manner in neuroblastoma SK-N-BE cells; in fact, in presence of M1 antagonist pirenzepine, ERK1/2 and AKT phosphorylation, induced by SOD1, was strongly prevented. This evidence concerns the gene AKT1 and neuroblastoma.