Our previous data showed the secretion of SOD1 in many cellular lines (Mondola et al., 1996, 1998, 2002); in addition, further cytofluorimetric studies demonstrated a specific SOD1 interaction with the plasmamembrane of neuroblastoma SK-N-BE cells that results in an activation of phospholipase C (PLC) transductional mechanisms associated to a slight increase of intracellular calcium concentration (Mondola et al., 2004; Damiano et al., 2013). Here, SOD1 is linked to neuroblastoma.