INS and early-onset autosomal dominant Alzheimer disease: In addition, dysfunction in fatty acid metabolism is implicated in disease conditions, such as cardiovascular disease, metabolic syndrome, type 2 diabetes, obesity, hypertension and proimflammatory conditions, as well as in several neurological diseases related to the alteration of insulin equilibrium in brain, as observed in Parkinson's disease, Alzheimer's disease and some forms of the schizophrenic spectrum disorders (Virmani et al., 2015).