Foxp3 can depress the activation of immune cells and their migration to myocardium (Matsumoto et al., 2011), reduce the cardiac interstitial inflammatory cell infiltration and the secretion of cytokines, and then ameliorate cardiac hypertrophy and myocardial damage induced by angiotensin II (AngII) or high blood pressure. This evidence concerns the gene AGT and cardiac hypertrophy.