The design of sorafenib/OSU-2S combination was based on the ability of sorafenib to induce p53 family-dependent apoptosis in HCC and the lack of functional p53 in most HCC cells which could be a possible mechanism for sorafenib resistance (Brost et al., 2013; Wei et al., 2015). The gene discussed is TP53; the disease is hepatocellular carcinoma.