Together, the results suggested that in 7,8-DHF-treated group, significant differences were found in the expression of p-TrkB, p-AKT, and p-GSK3β, which suggested that 7,8-DHF might play a role in ameliorate cognitive impairment in ApoE-KO mice by regulating AKT/GSK3β pathway. The gene discussed is APOE; the disease is Cognitive impairment.