EE exposure for 6 months was able to restore the impaired hippocampal neurogenesis of a triple transgenic AD-like mouse model (3xTg-AD, a model harboring human mutations in: APP (Swedish, KM670/671NL), Tau (MAPT P301L) and Presenilin 1 (PSEN1 M146V) (Rodríguez et al., 2008, 2011). This evidence concerns the gene APP and Alzheimer disease.