During ischemia, the expression level of Nrf2 is enhanced, and it is partly released from Keap1 and translocated to the nucleus, where it triggers the expression of several dozen cytoprotective proteins, such as HO-1 and NAD(P)H (Saleem et al., 2008; Tulsulkar and Shah, 2013). The gene discussed is KEAP1; the disease is ischemia.