In a univariate analysis, we found that serum TGF-β1 levels were higher in SSc patients with lung fibrosis (p = 0.004), digital ulcer (p = 0.02), and positive antitopoisomerase I (p = 0.04) compared to patients without these manifestations (Table 2). The gene discussed is TGFB1; the disease is pulmonary fibrosis.