When SSc patients were classified into cases of lSSc and dSSc, both lSSc patients [81.94 (39.44–134.0)] and dSSc [(100.1 (58.50–191.5)] patients had significantly higher TGF-β1 levels compared to healthy controls (p = 0.001 and p < 0.0001, resp). Here, TGFB1 is linked to systemic sclerosis.