The suggested mechanism includes three phases: (i) an activation of TEM1 expression in perivascular cells and stromal fibroblasts by unknown factor, (ii) a modulation of tissue proteases resulting from interaction between TEM1 and extracellular matrix components that is pericytes or fibroblasts, and (iii) tumor vessels maturation and induction of cell-to-cell attachments and cells migration. This evidence concerns the gene CD248 and neoplasm.