Following analysis of mRNA and protein expression profiles of exosome vesicles, Kucharzewska et al. demonstrated that intercellular signals such as IL-8, platelet-derived growth factors, and caveolin 1 specific to hypoxic microenvironment were modulated by secreted exosome-like vesicles in glioblastoma multiforme to activate vascular cells during tumor development [114]. Here, CXCL8 is linked to neoplasm.