FLT3 and acute myeloid leukemia: For example, FLT3 gene mutations have an internal tandem duplication of the juxta-membrane domain (FLT3/ITD), which results in chemotherapeutic resistance in acute myeloid leukemia and subsequent decreases in the progression-free survival of patients at 4 years relative to FLT3/wild-type patients (31% versus 55%) [7].