FGF2 and neoplasm: Many studies have suggested that TAMs secreted proteins, including MMPs, plasmin, urokinase-type plasminogen activator, vascular endothelial growth factor (VEGF), interleukin (IL)-8, basic fibroblast growth factor (bFGF), thymidine phosphorylates, phosphatidylinositol-glycan biosynthesis class F protein, and gastrin-releasing peptide that can cause angiogenesis in tumor tissue [11, 18, 19].