In the miRNA signatures of PD, we found the miRNAs with dramatic change of expression, included miR-196a-5p, -196b-5p, -10b-3p, -10a-5p, -615-3p, -505-5p, -144-5p, -542-3p, -200a-3p, -182-5p and -451a that expressed in the body fluids and associated with mutant α-synuclein aggregation. Here, SNCA is linked to Parkinson disease.