GPT and Cirrhosis: Similarly, elevated HBV DNA levels, alanine aminotransferase (ALT) levels, and hepatitis B virus envelope antigen (HBeAg) status are among the most important determinants of risk of progression to cirrhosis, whereas HBV DNA levels (>2,000 IU/mL), HBeAg status, and cirrhosis are the key predictors of HCC incidence [15].