GNAQ and thrombotic microangiopathy: Our previous work has demonstrated that Gnaq-/- chimeric mice possess several features of autoimmune disease, including production of autoreactive antibodies, deposition of IgG2a- and IgG2c-containing immune complexes in the kidney, thrombotic microangiopathy, a reduction in the number of red blood cells, synovitis, bone resorption, exostotic bone development, and osteolytic activity [12].