Our high-through-put first-step screening demonstrated coding and non-coding transcripts, the former confirmed ameloblastoma-specific protein encoding genes including parathyroid associated hormone-like proteins, amelotin and laminin [20–22], as well as functional pathway previously not reported but shared by other neoplasms including spliceosome, mRNA surveillance, Wnt and Notch signalling pathways. Here, LAMB2 is linked to ameloblastoma.