The detailed molecular mechanism of ARBs on cancer cells is still not well understood, but there seems to be a good amount of evidence for the potential role of the local renin-angiotensin system in carcinogenesis [75], and there are reports on the effect of angiotensin II type-1 receptor (AT1R) antagonists in suppressing the growth of gastric cancer cells [76] and preventing angiogenesis and growth of xenograft tumors developed by human bladder cancer cells [77]. This evidence concerns the gene REN and urinary bladder cancer.