Institution of routine testing for microalbuminuria in human patients with hematuria and a family history of AS or renal failure without obvious cause may help ensure early clinical detection of AS.[40] From a clinical standpoint, early detection of proteinuria is paramount to early institution of therapy (e.g., ACE inhibition) that slows disease progression and helps extend life expectancy.[40, 41]. The gene discussed is ACE; the disease is Renal insufficiency.