STK11 and lung adenocarcinoma: Included in the panel were the cell lines A549 (lung adenocarcinoma) and BxPC-3 (pancreatic adenocarcinoma), which have been previously shown to be particularly sensitive to the growth-inhibitory effects of metformin because of mutations in LKB1 (STK11)(A549) or mitochondrial complex I (BxPC3) [56, 57].