SF1 and myelodysplastic syndrome: RUNX, ZRSR2, and SF1 have also been reported in MDS [35, 36]; RUNX1 plays an important role in regulating the transcription of many tumor-suppressor genes [37], while ZRSR2 is an essential component of the splicing machinery [36], and SF1 is a component of the RNA-splicing machinery [36].