A g-protein-coupled receptor (GPCR), free fatty acid 2 receptor (FFA2; GPR43), expressed in pancreatic beta (β) cells contributes to glucose stimulated insulin secretion (GSIS) [4,5], and Ffar2 levels in islets are elevated during pregnancy suggesting a potential role for FFA2 in the β cell response to gestational insulin resistance [6,7]. This evidence concerns the gene INS and Insulin resistance.