It has recently been observed that SNPs previously associated with neurological and psychiatric conditions may be highly concentrated in the regions of long noncoding RNA genes.85 Furthermore, the apparent lack of exonic polymorphisms among genome-wide significant associations of psychiatric disorders may suggest that alterations in gene expression rather than protein structure could be the molecular mechanism leading to these conditions.86, 87 Such eQTL effect of SNPs in NOTCH1 gene may also indicate that a pathway other than NOTCH1 could underlie the current findings. The gene discussed is NOTCH1; the disease is psychiatric disorder.