The volumes of cortical grey matter and SFG were significantly negatively correlated with IL-6 and SERPINA3 mRNAs for both the whole cohort and the schizophrenia group only (all −0.700<r<−0.341, P<0.01; Supplementary Table 4 and Supplementary Figure 2). The gene discussed is SERPINA3; the disease is schizophrenia.