In fact, by using activated microglia as neuro-inflammatory markers, neuro-inflammation has previously been identified across multiple brain regions in individuals with schizophrenia using positron emission tomography (PET) imaging,63, 64 though not every study finds an increase.65 Using the first-generation translocator protein 18 kDa (TSPO) ligand [11C]PK11195, Doorduin et al.64 found numerically increased binding potentials in the frontal, occipital, temporal and parietal lobes, although this only reached statistical significant in the temporal lobe. The gene discussed is TSPO; the disease is schizophrenia.