FMR1 and fragile X-associated tremor/ataxia syndrome: This difference could have several explanations including that (a) the Brasa et al. study50 performed correlation analyses for different CpG sites, (b) used FM males as opposed to PM females without FXTAS, (c) had a much smaller sample size of only seven individuals (susceptible to the effects of outliers) or most likely (d) used a different normalisation strategy of FMR1 mRNA.