DUSP4 and myeloid sarcoma: While the positive regulation of MKP-2 on NO production would enhance disease pathogenesis as NO is known to contribute to the inflammatory response and demyelination of MS/EAE, the difference of NO levels only shown on day 28 but not day 17 after immunisation may suggest a dominant role of MKP-2 in modulating the adaptive immune response in the development of EAE through its effect on antigen presenting DC function, rather than macrophages.