Estrogen can also upregulate IL-17 expression, thereby eliminating IL-17 showed the more drastic effect in female SjS mice with a significant decrease in inflammatory cytokines and chemokines MIP-1β, MCP-1, IL-3, TNF-α, and IFN-γ whereas Eotaxin and GM-CSF were equally affected in both sexes. The gene discussed is IL17A; the disease is Schwartz-Jampel syndrome.