ARID1A and neoplasm: In this analysis, we found that the presence of loss-of-function ARID1A mutations in tumour cell lines was associated with sensitivity to VX-970 (P=0.0059, Student's t-test, Fig. 2j and Supplementary Data 3), although we were statistically underpowered to confirm whether or not the synthetic lethality was any more or less profound in particular tumour types in thisanalysis.