PMS2 and Fanconi anemia: This analysis identified several novel ATR synthetic lethal partner genes involved in DNA damage/repair including those targeting components of the HR/Fanconi Anaemia pathway (FANCE, SLX4, PALB2), DNA mismatch repair (MSH4, PMS2) and trans-lesion synthesis (RAD18) pathways (Fig. 1c and Supplementary Data 2).