Moreover, HDAC6 and alterations in α-tubulin acetylation have been associated with several human disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and Charcot–Marie–Tooth disease (CMT) [9–13]. The gene discussed is HDAC6; the disease is early-onset autosomal dominant Alzheimer disease.