In our mutant HSPB1-induced CMT2 mouse model, we suggest a dual hypothesis where HDAC6 transports polyubiquitinated proteins, such as mutated HSPB1, to the aggresome but, in turn, deacetylates the microtubules causing a block of axonal transport. Here, HSPB1 is linked to Charcot-Marie-Tooth disease type 2.