NOS1 and erectile dysfunction: This was done by measuring locomotor coordination in FNZ-administered mice after chronic pretreatment with NG-nitro-l-arginine methyl ester (l-NAME)—a nonselective inhibitor of the NOS isoforms, 7-nitroindazole (7-NI)—a preferential inhibitor of nNOS, l-arginine—a substrate for NO formation and sildenafil—a phosphodiesterase type 5 (PDE5) inhibitor that enhances the effects of NO by inhibiting cGMP degradation and is commonly used in erectile dysfunction.