Furthermore, rare loss-of-function and missense MME variants were recently associated to late onset dominant axonal polyneuropathies (Charcot-Marie-Tooth Neuropathy Type 2, CMT2; spinocerebellar ataxia with neuropathy, SCA43) [38, 39] and to a rare autosomal recessive variant of CMT2 [40]; none of the neuropathy patients described in these studies was reported to have migraine or CH symptoms, however individuals with MME mutations were reported to experience painful sensations [38]. This evidence concerns the gene MME and cyclic hematopoiesis.