TAC1 and cyclic hematopoiesis: They include peptides, such as substance P, neuropeptide Y, bradykinin, enkephalins, and atrial and brain natriuretic peptides [34], involved in the central regulation of pain, vasomotion, stress and sleep-wake rhythms as well as in the modulation of trigeminal nociceptive signals, whose alterations are thought to be implied in CH and to lead to the principal clinical features of this disease [3, 35, 36].