An et al. also described overexpression of Interleukin-6 (IL-6) in their CC sample cohort, a cytokine that is well known to be a potent mitogen as well as a major proinflammatory factor in CC [118], and found that IL-6 induces DNA hypermethylation, thereby effectively suppressing the expression of miRNA-370 from the nonimprinted maternal allele [80]. This evidence concerns the gene IL6 and cholangiocarcinoma.