Indeed, the expression levels of Drosha and Dicer are down-regulated in ovarian cancer (Kobel, Gilks & Huntsman, 2009) and neuroblastomas (Lin et al., 2010), while DGCR8 is up-regulated in esophageal cancer (Sugito et al., 2006), bladder cancer (Catto et al., 2009), and prostate cancer. The gene discussed is DROSHA; the disease is ovarian cancer.