In rodent species, the human vaccine cannot be used to assess function directly due to lack of homology, however, species‐specific mimetic vaccines containing murine homologues of the Y and P peptides conjugated to Qb‐VLP was shown to be capable of breaking B cell tolerance and induce anti‐IgE antibodies than can lower serum IgE in a murine allergy model 36, 37. The gene discussed is IGHE; the disease is allergic disease.