Pathogenic mechanisms of EoE has been related with atopy, because a Th2-type immunologic response has been demonstrated in EoE, in which T cells, interleukin (IL)-5 expression, eosinophils and positive IgE immunostaining were shown to characterize the inflammatory infiltrate [21], in a similar way it appears in bronchial asthma. The gene discussed is IGHE; the disease is eosinophilic esophagitis.