Markers commonly used for immunohistochemical staining in the evaluation of hepatic tumors include polyclonal CEA, cytokeratin 8/18 pair, cytokeratin 7/20, hep par 1, Glypican-3, and AFP for hepatocellular carcinoma [25]; cytokeratin 7/19, cytokeratin 7/20, B-HCG, CEA, and mucin-1 for cholangicarcinoma [26], CD 34, CD31, and factor V111 for hemangiendothelioma; and cytokeratin 7/20 for metastatic liver disease. This evidence concerns the gene KRT7 and hepatocellular carcinoma.