We note that a number of the genes driving the association with extinction learning reside within recurrent CNVs implicated in schizophrenia including CLDN5, MFI2, ATP10A, SNRPN and CGNL1 (Supplementary Table 6).4, 28 We also identified a number of overlapping genes whose biological function remains to be well characterised, illustrating that our combined bioinformatics and functional analysis can identify the contribution to risk of genes that are not annotated sufficiently for traditional pathway analysis approaches. Here, CLDN5 is linked to schizophrenia.