The top CpG site was cg10636246 at 1q23.1 located within 1500 bp of the transcription start site of Absent in melanoma 2 (AIM2) (effect size = −0.0069, P = 2.53 × 10−27), an interferon-gamma-induced protein involved in the innate immune response by inducing caspase-1-activating inflammasome formation in macrophages. The gene discussed is IFNG; the disease is melanoma.