We have demonstrated kidney damage through the analysis of early kidney biomarkers (KIM-1, Cys-C, β2M), histological changes (tubular height, collagen deposit) and the induction of RAS/KKS endocrine genes (AT1R, B1R), and blood pressure increment, after the subchronic exposure to PM2.5. This evidence concerns the gene AGTR1 and Nephropathy.