We further show that Chd7 expression is increased by MIF in NSPCs in vitro, and that this effect is mediated by the transcription factor Pax6. In addition, based on the same mechanism, we find that CHD7 supports the proliferation of human ES- NSPCs, as well as the cell proliferation of GICs, suggesting that this molecule may represent a new therapeutic target in glioma. The gene discussed is MIF; the disease is glioma.