As could be expected, a group of genes that might play protective roles against renal fibrosis was simultaneously activated by exposure to the high dose of dietary GLs, including ski-interacting protein that inhibits TGFβ-mediated responses [53], Wnt-5b that inhibits activation of the canonical (pro-fibrotic) Wnt pathway [54] and matrix metalloproteinase 9 involved in digestion of ECM (Table 6). This evidence concerns the gene WNT5B and renal fibrosis.