Then the Logistic regression model confirmed that NEUT% is still associated with depression in hospitalized heart failure patients with the adjustment of age, BMI, number of members of the household, smoking index, New York Heart Association (NYHA) classification, hemoglobin, TC, LDL-C, creatinine, cystatin-C, TBIL and albumin (OR = 1.046, p < .001). This evidence concerns the gene CST3 and heart failure.