A part of the reason may be that anemia (counts and hemoglobin), dyslipidemia (TC and LDL-C), kidney dysfunction (BUN, creatinine and cystatin-C) and liver dysfunction (TBIL, DBIL and albumin) were classical features accompanied with heart function deterioration, as the heart function decreased, the symptoms of heart failure began to appear, which may cause the depression in this population [29–32]. Here, CST3 is linked to anemia (phenotype).