After the adjustment of age, BMI, number of members of the household, smoking index, New York Heart Association (NYHA) classification, hemoglobin, TC, LDL-C, creatinine, cystatin-C, TBIL and albumin, NEUT% is still significantly associated with depression in hospitalized heart failure patients (OR = 1.046, p < .001). The gene discussed is CST3; the disease is major depressive disorder.