SAG and intraepithelial neoplasia: At age of 6 month, both PtenPC-/-;Sag+/+ and PtenPC-/-;SagPC-/- mice developed various lesions, ranging from hyperplasia, low grade intraepithelial neoplasia (LGPIN), high grade intraepithelial neoplasia (HGPIN), as well as adenocarcinoma.