In hyperlipidemia, the variation in lipid and lipoprotein levels can upset the balance between pro- and anticoagulant pathways, as well as provide a surface for the activation of pro-coagulation enzymatic complexes, namely, the activation of the surface increased factor Xa and factor Xa/Va-mediated factor VII (Kjalke et al. The gene discussed is F10; the disease is hyperlipidemia.