C3 and dense deposit disease: Dense deposit disease, formerly known as membranoproliferative glomerulonephritis type II, is a renal disorder characterized by unchecked AP activation in the plasma and high levels of C3 deposition on the glomeruli, with severe impairment of the kidney’s draining functions [32, 33]; as its name suggests electron-dense intramembranous deposits form within the glomerular basement membrane, a specialized extracellular matrix of the kidney.