CXCL8 and familial hyperaldosteronism: In this regard, FH might have a direct anti-inflammatory and tolerogenic activity towards infiltrated leukocytes, as suggested by the recent observation that monocyte-derived dendritic cells that have been treated with FH have lower expression of maturation markers and costimulatory molecules, decreased production of pro-inflammatory Th1-cytokines (i.e., IL-12, TNF, IFN-γ, IL-6, and IL-8), and preferential production of immunomodulatory mediators (i.e., IL-10 and TGF-β) [114].