Interestingly, sera from patients with early stage, non-metastatic, non-small cell lung cancer were found to contain autoantibodies against FH, where these recognize a conformationally distinct (reduced) form of the protein that is believed to be displayed only on the surface of tumor cells [180]; the autoantibodies interact with CCP 19 and inhibit the binding of FH to lung carcinoma cells, thereby promoting the deposition of C3b and increasing complement mediated tumor cell lysis. This evidence concerns the gene C3 and neoplasm.