Including only those variables with a linear relationship with choroidal thickness into multivariable analysis (age, CRP, urine protein/creatinine ratio [P:Cr], IL-6, ET-1, and ADMA) demonstrated that CRP, proteinuria, and IL-6 were independent predictors of choroidal thickness in CKD at locations I and II. The gene discussed is IL6; the disease is chronic kidney disease.