MMP-2 at a cut off value of more than 742 ng/ml has a sensitivity of 85.7% and specificity of 71.4% in identifying significant fibrosis (Fig. 2D) and at a cut off value of more than 747 ng/ml had a sensitivity of 85.7% and specificity of 64.6% in identifying cirrhosis. This evidence concerns the gene MMP2 and Cirrhosis.