There were strong positive relation between Af-Gc levels and ALB, CHE, ALT, AST (P = 0.001, < 0.001, < 0.001, < 0.001, respectively); Af-Gc globulin was correlated with Child-Pugh score in liver failure patients (r = – 0.313, P = 0.02). The gene discussed is ALB; the disease is liver failure.