HOXB8 and Decreased total neutrophil count: Still, all previous and current attempts to use mouse models for NE mutation-induced neutropenia have failed to reproduce the phenotype observed in humans.A possible explanation for the lack of impairment of survival and of differentiation block in our Hoxb8 model, despite the clear reproduction of ER stress, could be the existence of fundamentally different hematopoiesis regulation in humans versus mice.